Patients

We recently caught up with five patients who now have a second chance at health because of discoveries made at Baylor Scott & White Research Institute. From clinical trials related to high cholesterol and diabetes to cancer and hepatitis, watch their remarkable stories:

Hepatitis C
Harold Bowles
Melanoma
Teri Rodgers
Cholesterol
John Mihalopoulos
Type 1 Diabetes
David Brigance
Aortic Valve Replacement
Joaquin Provencio

Hepatitis C Treatment Gives New Hope to Texas Rancher

A late-night car accident more than 40 years ago resulted in Harold Bowles’ receiving nine units of blood. Six years after that, he was diagnosed with Hepatitis C and eventually developed cirrhosis of the liver. Four decades and two liver transplants later, Harold had lost hope. Find out what happened when he enrolled in a Baylor Scott & White Research Institute Hepatitis C clinical trial.

Mother of Two Credits Clinical Trial for Saving her Life

Many people envision skin cancer as being detectable by an enlarged mole or dark area of the skin. The truth is, the disease can’t always be seen. For Teri Rodgers, who was diagnosed with Stage 3-4 melanoma in 2007, the knot in her armpit clued her in. After two years of aggressive treatment, the cancer seemed to be defeated, but it returned six months later. Find out what happened when Teri took the next step and enrolled in a melanoma vaccine clinical trial.

Cholesterol Research Helps Active Dad Get Back to Life

Born with a genetic disorder that caused his body to produce too much cholesterol, John Mihalopoulos enrolled in a clinical trial after it became clear that he wasn’t responding to the available prescription drugs. As an active, 50-year-old cyclist and father of four, John wanted an alternative that would combat his condition while giving him the strength and endurance to live his life. Watch John’s story to learn more about his involvement in the clinical trial.

Type 1 Diabetes Patient Tries Experimental Drug in New Clinical Trial

It may have been trauma from a car wreck that triggered David Brigance’s Type 1 diabetes more than 30 years ago. As a result of that accident, his pancreas was damaged, preventing him from producing normal amounts of insulin. David explains what happened when he tried a new experimental drug designed to improve quality of life for Type 1 diabetics.

New Mexico Man Gets Aortic Valve Replacement—and a New Lease on Life

His symptoms started with a loss of energy and shortness of breath, but Joaquin Provencio assumed these were side effects of a medication he’d started taking. After seeing several doctors and heart specialists, Joaquin learned that his aortic valve was only functioning at 33 percent. With his condition deteriorating quickly and hopes for surgery dashed by a physician who refused to operate because of his age—he was 86 years old at the time—Joaquin enrolled in a Transcatheter Aortic Valve Replacement (TAVR) clinical study. Watch his story in the video.

2014-15 Numbers Highlights

379Total patents & patent applications
150
Total issued patents

16
Pending PCT patent applications
36 invention disclosures
10
newly filed provisional patent applications
9 newly filed
PCT applications

24 issued
patents
$793,632
Revenue generated from IP agreements per FY
49 Newly executed MTAs
10Newly Executed Data Sharing/Data
Use Agreements
9
Research collaboration agreements

Award Highlights

Jacqueline O'Leary, MD, MPH

Clinical Science Investigator Award
American Society of Transplantation

Virginia Pascual, MD

2014 Excellence in Healthcare Awards Achievement in Medical Research
D CEO, D Healthcare Daily

C. Richard Boland, MD

William Beaumont Prize in Gastroenterology
American Gastroenterological Association

Lifetime Achievement Award
Collaborative Group of the Americas on Inherited Colorectal Cancer

190 Gastroenterologists to Know
Becker’s ASC Review

Michael J. Mack, MD

Transcatheter Cardiovascular Therapeutics Career Achievement Award
Cardiovascular Research Foundation

Arianne L. Theiss, PhD

New Investigator Award
Gastrointestinal and Liver (GI&L) Physiology Section of the American Physiological Society

Dario Kivelivetch, MD

Psoriasis Foundation Amgen Medical Dermatology Fellowship
National Psoriasis Foundation

Mark Millard, MD

Appointed the Wanda and Collins Endowed Chair in Pulmonology

Select Publications by Category

Cardiology, Cardiac, Vascular And Thoracic Surgery

Assessing the risk of aortic valve replacement for severe aortic stenosis in the Transcatheter valve era.

Mathew V, Greason KL, Suri RM, Leon MB, Nkomo VT, Mack MJ, Rihal CS, Holmes DR Jr. Mayo Clin Proc 2014;89(10):1427-1435.

Novel markers and therapies for patients with acute heart failure and renal dysfunction.

McCullough PA, Jefferies JL. Am J Med 2014 Nov 13 [Epub ahead of print].

Morphologic features of the recipient heart in patients having cardiac transplantation and analysis of the congruence or incongruence between the clinical and morphologic diagnoses.

Roberts WC, Roberts CC, Ko JM, Filardo G, Capehart JE, Hall SA. Medicine (Baltimore) 2014;93(5):211-235.

Dermatology

Ponesimod—a future oral therapy for psoriasis?

Ryan C, Menter A. Lancet 2014;384(9959):2006-2008.

Editorials and Miscellaneous

Increasing the supply of kidneys for transplantation by making living donors the preferred source of donor kidneys.

Testa G, Siegler M. Medicine (Baltimore) 2014;93(29):e318.

Health Care Research And Improvement

Introducing Choosing Wisley®: next steps in improving healthcare value.

Horwitz LI, Masica AL, Auerbach AD. J Hosp Med 2014 Dec 30 [Epub ahead of print].

Patient-centered medical home features and expenditures by Medicare beneficiaries.

Stockbridge EL, Philpot LM, Pagán JA. Am J Manag Care 2014;20(5):379-385.

Documentation of use of the 5As for smoking cessation by primary care physicians across six health care delivery systems.

Williams RJ, Masica AL, McBurnie M, Solberg L, Bailey SR, Hazlehurst B, Kurtz SE, Williams AE, Puro JE, Stevens VJ. Am J Manag Care 2014;20(3):e35-e42.

Infectious Diseases

Microsporidiosis acquired through solid organ transplantation: a public health investigation.

Hocevar SN, Paddock CD, Spak CW, Rosenblatt R, Diaz-Luna H, Castillo I, Luna S, Friedman GC, Antony S, Stoddard RA, Tiller RV, Peterson T, Blau DM, Sriram RR, da Silva A, de Almeida M, Benedict T, Goldsmith CS, Zaki SR, Visvesvara GS, Kuehnert MJ; Microsporidia Transplant Transmission Investigation Team. Ann Intern Med 2014;160(4):213-220.

Internal Medicine And Family Medicine

Schizophrenia

Holder SD, Wayhs A. Am Fam Physician 2014;90(11):775-82.

FPIN’s clinical inquiries. Fish oil for treatment of dyslipidemia.

Narla R, Peck SB, Qui KM. Am Fam Physician 2014;89(4):288, 290.

Clinical inquiry: is there a primary care tool to detect aberrant drug-related behaviors in patients on opioids?

Peck SB, Gilchrist J, Clemans-Taylor L. J Fam Pract 2014;63(3):162-164.

Metabolic Diseases

Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States.

Kwan A, Abraham RS, Currier R, Brower A, Andruszewski K, Abbott JK, Baker M, Ballow M, Bartoshesky LE, Bonilla FA, Brokopp C, Brooks E, Caggana M, Celestin J, Church JA, Comeau AM, Connelly JA, Cowan MJ, Cunningham-Rundles C, Dasu T, Dave N, De La Morena MT, Duffner U, Fong CT, Forbes L, Freedenberg D, Gelfand EW, Hale JE, Hanson IC, Hay BN, Hu D, Infante A, Johnson D, Kapoor N, Kay DM, Kohn DB, Lee R, Lehman H, Lin Z, Lorey F, Abdel-Mageed A, Manning A, McGhee S, Moore TB, Naides SJ, Notarangelo LD, Orange JS, Pai SY, Porteus M, Rodriguez R, Romberg N, Routes J, Ruehle M, Rubenstein A, Saavedra-Matiz CA, Scott G, Scott PM, Secord E, Seroogy C, Shearer WT, Siegel S, Silvers SK, Stiehm ER, Sugerman RW, Sullivan JL, Tanksley S, Tierce ML 4th, Verbsky J, Vogel B, Walker R, Walkovich K, Walter JE, Wasserman RL, Watson MS, Weinberg GA, Weiner LB, Wood H, Yates AB, Puck JM, Bonagura VR. JAMA 2014;312(7):729–738.

Nephrology

Albuminuria

Emmett M. Cleve Clin J Med 2014;81(6):345.

Neurology, Neurosurgery, Spinal Surgery

Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.

Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Lynch JR, Zaidat OO, Rumboldt Z, Cloft HJ; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators. Lancet 2014;383(9914):333–341. BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety. Fox RJ, Kita M, Cohan SL, Henson LJ, Zambrano J, Scannevin RH, O’Gorman J, Novas M, Dawson KT, Phillips JT. Curr Med Res Opin 2014;30(2):251–262.

Oncology, Hematology, Surgical Oncology, Bone Marrow Transplantation

Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials.

EBCTCG (Early Breast Cancer Trialists’ Collaborative Group; O’Shaughnessy J), McGale P, Taylor C, Correa C, Cutter D, Duane F, Ewertz M, Gray R, Mannu G, Peto R, Whelan T, Wang Y, Wang Z, Darby S. Lancet 2014;383(9935):2127–2135.

Highlights

BSWH researcher develops biomarker for high-risk colon cancer metastases

BSWH researchers have found that the lipoprotein LOX-1 promotes humoral responses, which could allow researchers to design effective vaccines against microbial infections

Findings suggest that cold temperatures may prevent intense uterine bleeding during childbirth

BSWH babies are first to try padded bonnets in research effort that can prevent skull flattening and deformities

BSWH research shows that significant consumption of instant noodles may increase a person’s risk for heart disease

Articles

View highlights of 2014 bench research findings from Baylor:

Baylor Scott & White Health Research Could Lead to Development of Novel VaccinesBaylor Scott & White Health Research Uncovers Clues for Autoimmune DiseaseBaylor Scott & White Health Researcher Develops Biomarker for High-Risk Colon Cancer Metastases

Articles

View selected 2014 clinical research findings from Baylor:

Baylor Scott & White Health Babies are First to Try Padded Bonnets in Research EffortResearch: Valve Procedure Saves More Lives Than Open-Heart SurgeryUterine Cooling Can Reduce C-Section Blood Loss: Baylor Scott & White Health Study

Articles

View selected 2014 outcomes research findings from Baylor:

Can Instant Noodles Lead to Heart Disease, Diabetes and Stroke?Caregivers: Research Shows Opening Visitation Improves Patient Care

Baylor Scott & White Health Research Could Lead to Development of Novel Vaccines

The diverse functions of a special cell-recognition lipoprotein, LOX-1, weren’t always fully understood. However, BSWH researchers gained better insight into LOX-1’s role in immune responses through a study recently published in Immunity. Investigators found that the lipoprotein promotes humoral responses, which could allow researchers to design effective vaccines against microbial infections, including influenza viruses and HIV.

Read More >

Baylor Scott & White Health Research Uncovers Clues for Autoimmune Disease

BSWH researchers have a few more clues in the fight against autoimmune diseases and have recently published their work in Nature Immunology. Led by Baylor Scott & White Research Institute’s Hideki Ueno, MD, PhD, the study has helped scientists learn more about a special cell known to be involved in autoimmunity, in which the body attacks itself. That insight, according to the researchers, could someday change the treatment for autoimmune diseases, such as multiple sclerosis, lupus and rheumatoid arthritis.

Read More >

Baylor Scott & White Health Researcher Develops Biomarker for High-Risk Colon Cancer Metastases

A new study developed at the Center for Gastrointestinal Cancer Research and the Center for Epigenetics, Cancer Prevention and Cancer Genomics at Baylor Scott & White Research Institute has discovered unique metastasis-specific microRNA signatures in primary colorectal cancers that could predict prognosis and distant metastasis in colorectal cancer.

Read More >

Baylor Scott & White Health Babies are First to Try Padded Bonnets in Research Effort

New research from BSWH’s neonatal intensive care unit (NICU) could prevent a common infant problem through a never-before-seen wearable product. Recently approved by the FDA, the Invictus Medical Cranial Support Device (CSD) is an adjustable liquid-filled bonnet that’s specially designed to prevent an infant’s head from flattening. BSWH’s researchers were the first to test the new technology, which works by redistributing pressure on a baby’s soft skull.

Read More >

Research: Valve Procedure Saves More Lives Than Open-Heart Surgery

For the first time, a minimally invasive transcatheter valve – tested by Baylor Scott & White Research Institute in Dallas – has been shown to save more lives than open-heart surgery, according to new research revealed at the American College of Cardiology’s 2014 Scientific Sessions and published in The New England Journal of Medicine.

Read More >

Uterine Cooling Can Reduce C-Section Blood Loss: Baylor Scott & White Health Study

A never-before-seen childbirth technique could help a woman’s body heal itself through temperature changes, according to a pilot study from the Baylor Scott & White Research Institute. In a finding that could someday decrease global maternal mortality, BSWH’s team found that cooling a woman’s uterus after a C-section can dramatically reduce postpartum blood loss.

Read More >

Can Instant Noodles Lead to Heart Disease, Diabetes and Stroke?

Instant noodle eaters take heed. Recent BSWH research shows that significant consumption of the convenient food product – ramen included – may increase a person’s risk for cardiometabolic syndrome, especially in women. The findings, which were recently published in The Journal of Nutrition, could shed new light on the risks of a dietary habit held by a large part of the world.

Read More >

Caregivers: Research Shows Opening Visitation Improves Patient Care

Regardless of the circumstances, hospitalization can be a fearful thing. Patients find themselves in a new environment, surrounded by new people, new sights, new sounds – and often, the only thing that can quell that strange sense of unfamiliarity is having a loved one there to visit.

Read More >