
BSWH researcher develops biomarker for high-risk colon cancer metastases
Real innovation is right here, and it happens every day through clinical trials, new treatments and groundbreaking discoveries. Whether we’re studying new drugs, formulating new vaccines or boosting transplant outcomes, Baylor Scott & White Research Institute has helped to impact, extend and improve the lives of thousands of patients. We could tell you more about how our research has changed their lives, but we’d rather let you hear it from some of them in their own words.
A late-night car accident more than 40 years ago resulted in Harold Bowles’ receiving nine units of blood. Six years after that, he was diagnosed with Hepatitis C and eventually developed cirrhosis of the liver. Four decades and two liver transplants later, Harold had lost hope. Find out what happened when he enrolled in a Baylor Scott & White Research Institute Hepatitis C clinical trial.
Many people envision skin cancer as being detectable by an enlarged mole or dark area of the skin. The truth is, the disease can’t always be seen. For Teri Rodgers, who was diagnosed with Stage 3-4 melanoma in 2007, the knot in her armpit clued her in. After two years of aggressive treatment, the cancer seemed to be defeated, but it returned six months later. Find out what happened when Teri took the next step and enrolled in a melanoma vaccine clinical trial.
Born with a genetic disorder that caused his body to produce too much cholesterol, John Mihalopoulos enrolled in a clinical trial after it became clear that he wasn’t responding to the available prescription drugs. As an active, 50-year-old cyclist and father of four, John wanted an alternative that would combat his condition while giving him the strength and endurance to live his life. Watch John’s story to learn more about his involvement in the clinical trial.
It may have been trauma from a car wreck that triggered David Brigance’s Type 1 diabetes more than 30 years ago. As a result of that accident, his pancreas was damaged, preventing him from producing normal amounts of insulin. David explains what happened when he tried a new experimental drug designed to improve quality of life for Type 1 diabetics.
His symptoms started with a loss of energy and shortness of breath, but Joaquin Provencio assumed these were side effects of a medication he’d started taking. After seeing several doctors and heart specialists, Joaquin learned that his aortic valve was only functioning at 33 percent. With his condition deteriorating quickly and hopes for surgery dashed by a physician who refused to operate because of his age—he was 86 years old at the time—Joaquin enrolled in a Transcatheter Aortic Valve Replacement (TAVR) clinical study. Watch his story in the video.
The Baylor Scott & White Research Institute Innovation Office protects and commercializes BSWH’s intellectual property through patents. With more than 600 issued patents and pending applications—and more than $2.1 million generated from intellectual property (IP) agreements in 2014-2015 alone—the Innovation Office ultimately seeks to improve the lives of patients. In recent years, we have successfully licensed several hundred patents—from colorectal biomarkers to immunogenomic fingerprinting and many other areas of patient-focused research.
Our work at the Baylor Scott & White Research Institute is focused on the patient. It involves more than clinical trials and lab tests and brings research right to the patient’s bedside. And as a result of our successes in bench, clinical and outcomes trials and studies, researchers and centers alike have been recognized for their significant contributions to medicine with awards from notable organizations such as the Cardiovascular Research Foundation and the Texas Society of Vascular and Endovascular Surgeons.
Clinical Science Investigator Award
American Society of Transplantation
2014 Excellence in Healthcare Awards Achievement in Medical Research
D CEO, D Healthcare Daily
William Beaumont Prize in Gastroenterology
American Gastroenterological Association
Lifetime Achievement Award
Collaborative Group of the Americas on Inherited Colorectal Cancer
190 Gastroenterologists to Know
Becker’s ASC Review
Transcatheter Cardiovascular Therapeutics Career Achievement Award
Cardiovascular Research Foundation
New Investigator Award
Gastrointestinal and Liver (GI&L) Physiology Section of the American Physiological Society
Psoriasis Foundation Amgen Medical Dermatology Fellowship
National Psoriasis Foundation
Appointed the Wanda and Collins Endowed Chair in Pulmonology
Over the past year, many BSWH researchers have had their manuscripts published in esteemed science journals, from the Journal of the American Medical Association (JAMA) and the New England Journal of Medicine (NEJM) to many others. In doing so, these authors and co-authors have shared their investigative knowledge and findings with the medical community and have represented BSWH research worldwide. Congratulations to the researchers who have performed such groundbreaking medical research.
Assessing the risk of aortic valve replacement for severe aortic stenosis in the Transcatheter valve era.
Mathew V, Greason KL, Suri RM, Leon MB, Nkomo VT, Mack MJ, Rihal CS, Holmes DR Jr. Mayo Clin Proc 2014;89(10):1427-1435.Novel markers and therapies for patients with acute heart failure and renal dysfunction.
McCullough PA, Jefferies JL. Am J Med 2014 Nov 13 [Epub ahead of print].Morphologic features of the recipient heart in patients having cardiac transplantation and analysis of the congruence or incongruence between the clinical and morphologic diagnoses.
Roberts WC, Roberts CC, Ko JM, Filardo G, Capehart JE, Hall SA. Medicine (Baltimore) 2014;93(5):211-235.Ponesimod—a future oral therapy for psoriasis?
Ryan C, Menter A. Lancet 2014;384(9959):2006-2008.Increasing the supply of kidneys for transplantation by making living donors the preferred source of donor kidneys.
Testa G, Siegler M. Medicine (Baltimore) 2014;93(29):e318.Introducing Choosing Wisley®: next steps in improving healthcare value.
Horwitz LI, Masica AL, Auerbach AD. J Hosp Med 2014 Dec 30 [Epub ahead of print].Patient-centered medical home features and expenditures by Medicare beneficiaries.
Stockbridge EL, Philpot LM, Pagán JA. Am J Manag Care 2014;20(5):379-385.Documentation of use of the 5As for smoking cessation by primary care physicians across six health care delivery systems.
Williams RJ, Masica AL, McBurnie M, Solberg L, Bailey SR, Hazlehurst B, Kurtz SE, Williams AE, Puro JE, Stevens VJ. Am J Manag Care 2014;20(3):e35-e42.Microsporidiosis acquired through solid organ transplantation: a public health investigation.
Hocevar SN, Paddock CD, Spak CW, Rosenblatt R, Diaz-Luna H, Castillo I, Luna S, Friedman GC, Antony S, Stoddard RA, Tiller RV, Peterson T, Blau DM, Sriram RR, da Silva A, de Almeida M, Benedict T, Goldsmith CS, Zaki SR, Visvesvara GS, Kuehnert MJ; Microsporidia Transplant Transmission Investigation Team. Ann Intern Med 2014;160(4):213-220.Schizophrenia
Holder SD, Wayhs A. Am Fam Physician 2014;90(11):775-82.FPIN’s clinical inquiries. Fish oil for treatment of dyslipidemia.
Narla R, Peck SB, Qui KM. Am Fam Physician 2014;89(4):288, 290.Clinical inquiry: is there a primary care tool to detect aberrant drug-related behaviors in patients on opioids?
Peck SB, Gilchrist J, Clemans-Taylor L. J Fam Pract 2014;63(3):162-164.Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States.
Kwan A, Abraham RS, Currier R, Brower A, Andruszewski K, Abbott JK, Baker M, Ballow M, Bartoshesky LE, Bonilla FA, Brokopp C, Brooks E, Caggana M, Celestin J, Church JA, Comeau AM, Connelly JA, Cowan MJ, Cunningham-Rundles C, Dasu T, Dave N, De La Morena MT, Duffner U, Fong CT, Forbes L, Freedenberg D, Gelfand EW, Hale JE, Hanson IC, Hay BN, Hu D, Infante A, Johnson D, Kapoor N, Kay DM, Kohn DB, Lee R, Lehman H, Lin Z, Lorey F, Abdel-Mageed A, Manning A, McGhee S, Moore TB, Naides SJ, Notarangelo LD, Orange JS, Pai SY, Porteus M, Rodriguez R, Romberg N, Routes J, Ruehle M, Rubenstein A, Saavedra-Matiz CA, Scott G, Scott PM, Secord E, Seroogy C, Shearer WT, Siegel S, Silvers SK, Stiehm ER, Sugerman RW, Sullivan JL, Tanksley S, Tierce ML 4th, Verbsky J, Vogel B, Walker R, Walkovich K, Walter JE, Wasserman RL, Watson MS, Weinberg GA, Weiner LB, Wood H, Yates AB, Puck JM, Bonagura VR. JAMA 2014;312(7):729–738.Albuminuria
Emmett M. Cleve Clin J Med 2014;81(6):345.Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Lynch JR, Zaidat OO, Rumboldt Z, Cloft HJ; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators. Lancet 2014;383(9914):333–341. BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety. Fox RJ, Kita M, Cohan SL, Henson LJ, Zambrano J, Scannevin RH, O’Gorman J, Novas M, Dawson KT, Phillips JT. Curr Med Res Opin 2014;30(2):251–262.Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials.
EBCTCG (Early Breast Cancer Trialists’ Collaborative Group; O’Shaughnessy J), McGale P, Taylor C, Correa C, Cutter D, Duane F, Ewertz M, Gray R, Mannu G, Peto R, Whelan T, Wang Y, Wang Z, Darby S. Lancet 2014;383(9935):2127–2135.At the Baylor Scott & White Research Institute, we have some of the world’s most renowned researchers on our investigative roster. Thanks to their efforts, as well as those of our research staff, a suite of innovative research findings surfaced in the past year that are already helping patients across the world experience improved healing and better quality of life. From research conducted through clinical trials, in the laboratory and even using outcomes data, these bench-to-bedside findings have impacted patients in profound ways.
BSWH researcher develops biomarker for high-risk colon cancer metastases
BSWH researchers have found that the lipoprotein LOX-1 promotes humoral responses, which could allow researchers to design effective vaccines against microbial infections
Findings suggest that cold temperatures may prevent intense uterine bleeding during childbirth
BSWH babies are first to try padded bonnets in research effort that can prevent skull flattening and deformities
BSWH research shows that significant consumption of instant noodles may increase a person’s risk for heart disease
Research conducted in Baylor labs has directly contributed to innovative vaccines, immunologic findings and the development of new drugs that are tested in clinical trials. Last year, such research developed a blood test that helps reveal colon cancer, and helped identify an immune cell that is involved in autoimmune disease.
View highlights of 2014 bench research findings from Baylor:
Baylor Scott & White Health Research Could Lead to Development of Novel VaccinesBaylor Scott & White Health Research Uncovers Clues for Autoimmune DiseaseBaylor Scott & White Health Researcher Develops Biomarker for High-Risk Colon Cancer MetastasesInvestigators build on research discoveries in the laboratory to conduct clinical trials, which enroll patients to determine the effectiveness and safety of new treatments, devices and medications. In the past year, clinical research conducted at participating Baylor sites has tested new wearable products to prevent an infant’s head from flattening, revealed a new procedure that outperforms open-heart surgery and identified a new dendritic cell vaccine for pancreatic cancer that will soon be tested in clinical trials.
View selected 2014 clinical research findings from Baylor:
Baylor Scott & White Health Babies are First to Try Padded Bonnets in Research EffortResearch: Valve Procedure Saves More Lives Than Open-Heart SurgeryUterine Cooling Can Reduce C-Section Blood Loss: Baylor Scott & White Health StudyQuality-of-care studies, otherwise known as outcomes research, or delivery science, explore the way health care is delivered and identify ways to improve it. Investigators involved in such efforts analyze how to lower cost, improve care and enhance population health on a larger scale. In 2014, such research showed the link between compliance and lower mortality; determined care, outcomes and costs for cases of diabetes, spine issues and other disease states; and more.
View selected 2014 outcomes research findings from Baylor:
Can Instant Noodles Lead to Heart Disease, Diabetes and Stroke?Caregivers: Research Shows Opening Visitation Improves Patient Care